Sarecycline

• It is necessary to check the pregnancy status of women before initiating sarecycline therapy as it may affect the unborn baby and cause some abnormalities such as permanent teeth discoloration, deficiency of teeth enamel or enamel hypoplasia, and may slow down the bone growth. • Patients must be advised to contact the doctor immediately if women become pregnant during the treatment with sarecycline. • Men wishing to have a child in future should use a sperm bank facility before starting the sarecycline therapy as sarecycline treatment can affect the fertility status in the male. • Clostridium difficile associated diarrhea (CDAD) can occur during the treatment and patients must be monitored for the presence of watery or bloody stools. Patients with such symptoms or signs should be treated appropriately with fluid and electrolyte management, protein supplementation, and antibiotic treatment for Clostridium difficile. • If CDAD infection is confirmed, the treatment with sarecycline must be stopped. In severe cases, a surgeon opinion can also be considered. • Sarecycline can cause dizziness or light-headedness. Therefore, patients must be advised not to get involved in tasks requiring mental alertness such as driving a vehicle, operating heavy machinery, or handling hazardous chemicals. • Patients should be carefully observed and treated under specialist care for any symptoms and signs of intracranial hypertension such as blurred vision or a headache.