CLONAZEPAM

USDailyMed:Clonazepam AU:B3 N03AE01(WHO) AU:S4(Prescription only)BR:Class B1(Psychoactive drugs)CA:Schedule IVDE: Prescription only (Anlage IIIfor higher doses)NZ: Class C5UK:Class CUS:Schedule IVUN:Psychotropic Schedule IVIn general: ℞ (Prescription only) 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one 1622-61-3Y 2802 6963 DB01068Y 2700Y 5PE9FDE8GB D00280Y CHEBI:3756Y ChEMBL452Y DTXSID1022845 Interactive image O=C1CN=C(c2ccccc2Cl)c2cc([N+](=O)[O-])ccc2N1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)YKey:DGBIGWXXNGSACT-UHFFFAOYSA-NY Clonazepam, sold under the brand nameKlonopinamong others, is abenzodiazepinemedication used to prevent and treatanxiety disorders,seizures,bipolarmania, agitation associated withpsychosis,obsessive–compulsive disorder(OCD), andakathisia.It is a long-actingbenzodiazepine.It possessesanxiolytic,anticonvulsant,sedative,hypnotic, andskeletal muscle relaxantproperties. It is typically takenorally(swallowed by mouth) but is also usedintravenously.Effects begin within one hour and last between eight and twelve hours in adults. Common side effects may includesleepiness,weakness,poor coordination, difficulty concentrating, and agitation. Clonazepam may alsodecrease memory formation.Long-term usemay result intolerance,dependence, and life-threateningwithdrawal symptomsif stopped abruptly.Dependence occurs in one-third of people who take benzodiazepines for longer than four weeks.The risk ofsuicideincreases, particularly in people who are already depressed.Use during pregnancy may result in harm to the fetus.Clonazepam binds toGABAAreceptors, thus increasing the effect of the chiefinhibitoryneurotransmitterγ-aminobutyric acid(GABA). Clonazepam was patented in 1960, marketed in 1964, and went on sale in 1975 in the United States fromRoche.It is available as ageneric medication.In 2023, it was the 62nd most commonly prescribed medication in the United States, with more than 10million prescriptions.In many areas of the world, it is commonly used as arecreational drug.