Jext

Pharmacotherapeutic group : adrenergic and dopaminergic agents, adrenaline. ATC code: C01 CA 24 Adrenaline is a naturally occurring catecholamine secreted by the adrenal medulla in response to exertion or stress. It is a sympathomimetic amine which is a potent stimulant of both alpha- and beta- adrenergic receptors and its effects on target organs are therefore complex.‍‍‍‍‍‍​​​‍​​​​​​ It is used to provide rapid relief of hypersensitivity reactions to allergies or to idiopathic or exercise-induced anaphylaxis. Adrenaline causes glucose to be released into circulation, oxygen consumption is increased. Blood flow to the kidneys, mucosa and skin is reduced. Adrenaline has a strong vasoconstrictor action through alpha- adrenergic stimulation. This activity counteracts the vasodilatation and increased vascular permeability leading to loss of intravascular fluid and subsequent hypotension, which are the major pharmacological features in anaphylactic shock. Adrenaline stimulates bronchial beta-adrenergic receptors and has a powerful bronchodilator action. Adrenaline also alleviates pruritus, urticaria and angioedema associated with anaphylaxis. The overall effect of adrenaline depends on the dose used, and may be complicated by the homeostatic reflex responses.