PIPERACILLIN AND TAZOBACTAM FOR INJECTION

J01CR05(WHO) AU:S4(Prescription only)CA:℞-onlyUS:℞-only 123683-33-0N 9918881 8094523Y ChEMBL436129Y DTXSID80894106 Piperacillin/tazobactam, sold under the brand nameTazocinamong others, is acombination medicationcontaining theantibioticpiperacillinand theβ-lactamase inhibitortazobactam.The combination has activity against manyGram-positiveandGram-negativebacteriaincludingPseudomonas aeruginosa.It is used to treatpelvic inflammatory disease,intra-abdominal infection,pneumonia,cellulitis, andsepsis.It is given byinjection into a vein. Common adverse effects includeheadache, trouble sleeping, rash, nausea,constipation, and diarrhea.Serious adverse effects includeClostridioides difficileinfectionandallergic reactionsincludinganaphylaxis.Those who are allergic to otherβ-lactamare more likely to be allergic to piperacillin/tazobactam.Use inpregnancyorbreastfeedingappears to generally be safe.Its mechanism usually results inbacterial deaththrough blocking their ability to make acell wall. Piperacillin/tazobactam was approved for medical use in the United States in 1993.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.