Clomipramine

Clomipramine is an antidepressant, antiobsessional, sedative, and anticholinergic agent belonging to the tricyclic antidepressant class. It is used, among other indications, for the treatment of depression, anxiety disorders, obsessive-compulsive disorders, and chronic pain. The dose is individually adjusted and therapy is initiated gradually. Clomipramine is a substrate of CYP450 isoenzymes and has a high potential for drug interactions. The most common possible adverse effects include dry mouth, excessive sweating, micturition disorders, weight gain, drowsiness, dizziness, tremor, headache, visual disturbances, and constipation. Clomipramine (ATC N06AA04) has antidepressant, antiobsessional, sedative, alpha-1-adrenolytic, anticholinergic, antihistaminic, and antiserotonergic properties. It inhibits the reuptake of noradrenaline and serotonin into the presynaptic neuron. The active metabolite desmethylclomipramine is formed by CYP2D6. The mean half-life is 21 hours for clomipramine and 36 hours for desmethylclomipramine. Mechanism of action of reuptake inhibitors, click to enlarge. Illustration © PharmaWiki