Propylthiouracil

AU:D H03BA02(WHO) In general: ℞ (Prescription only) 6-propyl-2-sulfanylpyrimidin-4-one 51-52-5Y 657298 6650 DB00550Y 571424Y 721M9407IY D00562Y CHEBI:8502Y ChEMBL1518Y DTXSID5021209 Interactive image S=C1N/C(=C\C(=O)N1)CCC InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)YKey:KNAHARQHSZJURB-UHFFFAOYSA-NY Propylthiouracil(PTU) is a medication used to treathyperthyroidism.This includes hyperthyroidism due toGraves' diseaseandtoxic multinodular goiter.In athyrotoxic crisisit is generally more effective thanmethimazole.Otherwise it is typically only used when methimazole, surgery, andradioactive iodineis not possible.It is takenby mouth. Common side effects include itchiness, hair loss, parotid swelling, vomiting, muscle pains, numbness, and headache.Other severe side effects includeliver problemsandlow blood cell counts.Use during pregnancy may harm the baby.Propylthiouracil is in theantithyroidfamily of medications.It works by decreasing the amount ofthyroid hormoneproduced by thethyroid glandand blocking the conversion ofthyroxine(T4) totriiodothyronine(T3). Propylthiouracil came into medical use in the 1940s.It is on theWorld Health Organization's List of Essential Medicines.