Pharmacotherapeutic group: Other anti-inflammatory and antirheumatic agents, non-steroids, ATC code: M01AX01
Mechanism of action
Nabumetone contains as active substance 4-(6´-methoxy-2´-naphthyl)-2-butanone
Nabumetone is a non-acidic non-steroidal anti-inflammatory agent which is a relatively weak inhibitor of prostaglandin synthesis.
Pharmacodynamic effects
A notable feature of the animal pharmacology is the lack of effect on the gastric mucosa. Nabumetone has a weak effect on platelet aggregation caused by collagen and no effect on bleeding time.
In humans, lower frequency of peptic ulcers, bleeding or perforation has been reported in comparison with other NSAIDs. Following absorption from the gastrointestinal tract nabumetone is rapidly metabolised in the liver to the principal active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) a potent inhibitor of prostaglandin synthesis.
