Mycophenolate Mofetil - Indications, Dosage, Side Effects and Precautions

USDailyMed:Mycophenolate mofetil AU:D mycophenolic acid:L04AA06(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only) (4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid mycophenolic acid:24280-93-1Y128794-94-5(mofetil ester),37415-62-6(sodium salt) mycophenolic acid:446541 mycophenolic acid:6832 mycophenolic acid:DB01024Y mycophenolic acid:393865Y mycophenolic acid:HU9DX48N0T mycophenolic acid:D05096Y mycophenolic acid:CHEBI:168396Y mycophenolic acid:ChEMBL866Y mycophenolic acid:DTXSID4041070 mycophenolic acid:Interactive imagemofetil ester:Interactive image mycophenolic acid: O=C1OCc2c1c(O)c(c(OC)c2C)C\C=C(/C)CCC(=O)Omofetil ester: COc1c(C​‍​​​​​‍​‍‍‍‍​‍‍)c2c(c(O)c1C/C=C(\C)CCC(=O)OCCN1CCOCC1)C(=O)OC2 mycophenolic acid: InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+YKey:HPNSFSBZBAHARI-RUDMXATFSA-NYmofetil ester: InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+Key:RTGDFNSFWBGLEC-SYZQJQIISA-N Mycophenolic acidis animmunosuppressant medicationused to preventrejectionfollowingorgan transplantationand to treatautoimmune conditionssuch asCrohn's diseaseandlupus.Specifically it is used followingkidney,heart, andliver transplantation.It can be given by mouth or by injection into a vein.It comes asmycophenolate sodiumandmycophenolate mofetil. Common side effects include nausea, infections, and diarrhea.Other serious side effects include an increased risk ofcancer,progressive multifocal leukoencephalopathy,anemia, andgastrointestinal bleeding.Use during pregnancy may harm the baby.It works by blockinginosine monophosphate dehydrogenase(IMPDH), which is needed bylymphocytesto makeguanosine. Mycophenolic acid was initially discovered by ItalianBartolomeo Gosioin 1893.It was rediscovered in 1945 and 1968.It was approved for medical use in the United States in 1995 following the discovery of its immunosuppressive properties in the 1990s.It is available as ageneric medication.In 2022, it was the 227th most commonly prescribed medication in the United States, with more than 1million prescriptions.