OSELTAMIVIR (OSELTAMIVIR PHOSPHATE)

USDailyMed:Oseltamivir AU:B1 J05AH02(WHO) AU:S4(Prescription only)UK:POM(Prescription only)US:℞-onlyEU:Rx-only ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)-cyclohex-1-ene-1-carboxylate 196618-13-0204255-11-8 65028 DB00198 58540 20O93L6F9H D08306as salt:D00900 CHEBI:7798 ChEMBL1229 DTXSID9044291 Interactive image CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1Key:VSZGPKBBMSAYNT-RRFJBIMHSA-N Oseltamivir, sold under the brand nameTamifluamong others, is anantiviral medicationused to treat and preventinfluenza Aandinfluenza B, viruses that causethe flu.Many medical organizations recommend it in people who have complications or are at high risk of complications within 48 hours of first symptoms of infection.They rec‍‍‍‍‍‍​​​‍​​​​​​ommend it to prevent infection in those at high risk, but not the general population.TheCenters for Disease Control and Prevention(CDC) recommends that clinicians use their discretion to treat those at lower risk who present within 48 hours of first symptoms of infection.It is taken by mouth, either as a pill or liquid. Recommendations regarding oseltamivir are controversial as are criticisms of the recommendations.A 2014Cochrane Reviewconcluded that oseltamivir does not reduce hospitalizations, and that there is no evidence of reduction in complications of influenza.Twometa-analyseshave concluded that benefits in those who are otherwise healthy do not outweigh its risks.They also found little evidence regarding whether treatment changes the risk of hospitalization or death in high risk populations.However, another meta-analysis found that oseltamivir was effective for prevention of influenza at the individual and household levels. Common side effects includevomiting,diarrhea, headache, and trouble sleeping.Other side effects may includepsychiatric symptomsandseizures.In the United States, it is recommended for influenza infections during pregnancy.It has been taken by a small number of pregnant women without signs of problems.Dose adjustment may be needed in those with kidney problems. Oseltamivir was approved for medical use in the US in 1999.It was the firstneuraminidase inhibitoravailable by mouth.It is on theWorld Health Organization's List of Essential Medicinesbut was downgraded to "complementary" status in 2017.Ageneric versionwas approved in the US in 2016.In 2023, it was the 250th most commonly prescribed medication in the United States, with more than 1million prescriptions.