NALOXONE HYDROCHLORIDE

USDailyMed:Naloxone AU:B1US: C A06AH04(WHO)V03AB15(WHO) AU:S4(Prescription only) / S3 (Pharmacist Only Medicine)BR:Class C1(Other controlled substances)CA:OTCDE: § 48AMG/§ 1MPAV(Prescription only)UK:POM(Prescription only)US:OTC/ Rx-onlyIn general: ℞ (Prescription only) (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-(prop-2-en-1-yl)-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofurano[3,2-e]isoquinolin-7(7aH)-one 465-65-6Y 5284596 1638 DB01183Y 4447644Y 36B82AMQ7N D08249Yas HCl:D01340Y CHEBI:7459N ChEMBL80Y DTXSID8023349 Interactive image O=C1[C@@H]2OC3=C(O)C=CC4=C3[C@@]2([C@]5(CC1)O)CCN(CC=C)[C@@H]5C4 InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)‍​‍‍‍​‍‍‍‍‍‍‍‍​‍24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1YKey:UZHSEJADLWPNLE-GRGSLBFTSA-NY Naloxone, sold under the brand nameNarcanamong others, is anopioid antagonist, a medication used to reverse or reduce the effects ofopioids.For example, it is used to restore breathing after anopioid overdose.Effects begin within two minutes when givenintravenously, five minutes wheninjected into a muscle,and ten minutes as anasal spray.Naloxone blocks the effects of opioids for 30 to 90 minutes. Administration to opioid-dependent individuals may cause symptoms ofopioid withdrawal, including restlessness, agitation, nausea, vomiting, afast heart rate, and sweating.To prevent this, small doses every few minutes can be given until the desired effect is reached.In those with previous heart disease or taking medications that negatively affect the heart, further heart problems have occurred.There is limited data on naloxone's safety during pregnancy.Naloxone is anon-selectiveandcompetitiveopioid receptor antagonist.It reverses the depression of the central nervous system and respiratory system caused by opioids. Naloxone was patented in 1961 and approved for opioid overdose in the United States in 1971.It is on theWorld Health Organization's List of Essential Medicines.