Anti-Androgens, ATC - Code L02 B B01
Flutamide is a non-steroidal antiandrogenic substance.
In animal studies, flutamide demonstrates potent antiandrogenic effects. It has been demonstrated to reduce prostate and seminal vesicle weights in intact immature rats and to prevent androgen-stimulated hypertrophy of these organs in castrated immature rats. Prostate weights in dogs and baboons were also reduced by flutamide treatment. It exerts its antiandrogenic effects attributable to its pharmacologically active metabolite, hydroxyflutamide, by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgens in target tissues. When flutamide is given in combination with surgical or medical castration, suppression of both testicular and adrenal androgen activity is achieved. Because flutamide is non-steroidal, Flutamide 250 mg Tablets demonstrates a low potential for cardiovascular side-effects.
