Lamivudine

USDailyMed:Lamivudine AU:B3 J05AF05(WHO) CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only 2',3'-dideoxy-3'-thiacytidine4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one 134678-17-4Y 60825 DB00709Y 66068Y 2T8Q726O95 D00353Y ChEMBL141Y 000388 3TC (PDBe,RCSB PDB) DTXSID7023194 Interactive image O=C1/N=C(/N)\C=C/N1[C@@H]2O[C@@H](SC2)CO InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m1/s1YKey:JTEGQNOMFQHVDC-RQJHMYQMSA-NY Lamivudine, commonly called3TC, is anantiretroviral medicationused to prevent and treatHIV/AIDS.It is also used to treat chronichepatitis Bwhen other options are not possible.It is effective against bothHIV-1andHIV-2.It is typically used in combination with other antiretrovirals such aszidovudine,dolutegravir, andabacavir.Lamivudine may be included as part ofpost-exposure preventionin those who have been potentially exposed to HIV.Lamivudine is taken by mouth as a liquid or tablet. Common side effects include nausea, diarrhea, headaches,feeling tired, and cough.Serious side effects includeliver disease,lactic acidosis, and worsening hepatitis B among those already infected.It is safe for people over three months of age and can be used duringpregnancy.The medication can be taken with or without food.Lamivudine is anucleoside reverse transcriptase inhibitorand works by blocking theHIV reverse transcriptaseand hepatitis B virus polymerase. Lamivudine was patented in 1995 and approved for use in the United States in 1995.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.