HealthdirectFree Australian health advice you can count on.

• Caution should be exercised in patients with history of chronic obstructive pulmonary disease (COPD), bowel obstruction, decrease in white blood cells, flu-like symptoms, hepatitis, any allergy, who are taking other medications, during pregnancy and b‍‍‍‍‍‍​​​‍​​​​​​reastfeeding. • Avoid live vaccination during the treatment period. • Avoid contact with people who have infections. • It may reduce platelet counts; avoid injury or bruising. • Patient may develop with increased risk of certain types of viral brain infection (progressive multifocal leukoencephalopathy [PML]) with the following symptoms: confusion, dizziness, difficulty in talking or walking, abnormal thinking, poor eyesight, imbalance, or weakness. If it is so consult with your doctor immediately.