DAPAGLIFLOZIN PROPANEDIOL; METFORMIN HYDROCHLORIDE

USDailyMed:Dapagliflozin AU:D A10BK01(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only) (2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol 461432-26-8 9887712 4594 DB06292 8063384 1ULL0QJ8UC D08897as salt:D09763 CHEBI:85078 ChEMBL429910 DTXSID20905104 Interactive image CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1 InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1Key:JVHXJTBJCFBINQ-ADAARDCZSA-N Dapagliflozin, sold under the brand namesFarxiga(US) andForxiga(EU) among others, is a medication used to treattype2 diabetes.It is also used to treat adults withheart failureandchronic kidney disease.It reversiblyinhibits sodium-glucose co-transporter 2(SGLT-2) in the renalproximal convoluted tubuleto reduce glucose reabsorption and increase urinary glucose excretion. Common side effects includehypoglycaemia(low blood sugar), urinary tract infections, genital infections, andvolume depletion(reduced amount of water in the body).Diabetic ketoacidosisis a common side effect in people withtype1 diabetes.Serious but rare side effects includeFournier gangrene. It was developed byBristol-Myers Squibbin partnership withAstraZeneca. It is on theWorld Health Organization's List of Essential Medicines.In 2023, it was the 92nd most commonly prescribed medication in the United States, with more than 7million prescriptions.Dapagliflozin is available as ageneric medication.