ABACAVIR SULFATE

USDailyMed:Abacavir AU:B3 J05AF06(WHO) AU:S4(Prescription only)UK:POM(Prescription only)US:℞-onlyEU:Rx-only {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol 136470-78-5Y 441300 DB01048Y 390063Y WR2TIP26VS D07057Y CHEBI:421707Y ChEMBL1380Y 028596 DTXSID4046444 Interactive image n3c1c(ncn1[C@H]2/C=C\[C@@H](CO)C2)c(nc3N)NC4CC4 InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1YKey:MCGSCOLBFJQGHM-SCZZXKLOSA-NY Abacavir(ABC), sold under the brand nameZiagenamong others, is amedicationused to treatHIV/AIDS.Similar to othernucleoside analogr‍​‍‍‍​‍‍‍‍‍‍‍‍​‍everse-transcriptase inhibitors(NRTIs), abacavir is used together with otherHIV medications, and is not recommended by itself.It is taken by mouth as a tablet or solution and may be used in children over the age of three months. Abacavir is generally well tolerated.Common side effects include vomiting,insomnia(trouble sleeping), fever, and feeling tired.Other common side effects include loss of appetite, headache, nausea (feeling sick), diarrhea, rash, and lethargy (lack of energy).More severe side effects includehypersensitivity,liver damage, andlactic acidosis.Genetic testingcan indicate whether a person is at higher risk of developing hypersensitivity.Symptoms of hypersensitivity include rash, vomiting, and shortness of breath.Abacavir is in the NRTI class of medications, which work by blockingreverse transcriptase, an enzyme needed forHIV virusreplication.Within the NRTI class, abacavir is acarbocyclic nucleoside. Abacavir was patented in 1988, and approved for use in the United States in 1998.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.Abacavir is used together with other HIV medications, such asabacavir/lamivudine/zidovudine,abacavir/dolutegravir/lamivudine, andabacavir/lamivudine.The combination abacavir/lamivudine is an essential medicine.