Diphenoxylate

USDailyMed:Diphenoxylate hydrochloride and atropine sulfate AU:C None UK:POM(Prescription only)US:Schedule V 55840-97-6 23724775 none D00301 CHEBI:6519 Diphenoxylate/atropine, also known asco-phenotropeand sold under the brand nameLomotilamong others, is used to treatdiarrhea.It is afixed-dose combinationof the medicationsdiphenoxylate, as the hydrochloride, anantidiarrheal; andatropine, as the sulfate, ananticholinergic.It is takenby mouth.Onset is typically within an hour. Side effects may include abdominal pain,angioedema,glaucoma,heart problems, feeling tired, dry mouth, and trouble seeing.It is unclear if use inpregnancyis safe and use whenbreastfeedingmay result in side effects in the baby.It works by decreasing contractions of the bowel. The combination was approved for medical use in the United States in 1960.It is available as ageneric medication.In 2023, it was the 286th most commonly prescribed medication in the United States, with more than 600,000 prescriptions.The combination is classified as aSchedule V controlled substancein the United States.