Cyclobenzaprine - Indications, Dosage, Side Effects and Precautions

USDailyMed:Cyclobenzaprine M03BX08(WHO) US:℞-onlyIn general: ℞ (Prescription only) 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-propan-1-amine 303-53-7Y 2895 7152 DB00924Y 2792Y 69O5WQQ5TI D07758Y CHEBI:3996Y ChEMBL669Y DTXSID0046933 Interactive image c3cc\2c(\C=C/c1c(cccc1)C/2=C/CCN(C)C)cc3 InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3YKey:JURKNVYFZMSNLP-UHFFFAOYSA-NY Cyclobenzaprine, sold under several brand names inclu​‍​​​​​‍​‍‍‍‍​‍‍ding, historically,Flexeril, is amuscle relaxerused formuscle spasmsfrommusculoskeletalconditions of sudden onset.It is not useful incerebral palsy.It is takenby mouth. Common side effects includeheadache, tiredness, dizziness, and dry mouth.Serious side effects may include anirregular heartbeat.There is no evidence of harm in pregnancy, but it has not been well studied in this population.It should not be used together withMAOIs.How it works is unclear.In any case, it is known toinhibitserotoninandnorepinephrinereuptakeand toblockserotonin,adrenergic,histamine, andmuscarinic acetylcholine receptors.Chemically, it is very similar totricyclic antidepressantslikeamitriptyline. Cyclobenzaprine was approved for medical use in the United States in 1977.It is available by prescription as ageneric medication.In 2023, it was the 47th most commonly prescribed medication in the United States, with more than 13million prescriptions.It was not available in the United Kingdom as of 2012.