Zoledronic Acid

USDailyMed:Zoledronic acid AU:B3 M05BA08(WHO) AU:S4(Prescription only)US:℞-onlyEU:Rx-only [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) 118072-93-8 68740 3177 DB00399 61986 70HZ18PH24 D08689ND01968N CHEBI:46557 ChEMBL924Y ZOL (PDBe,RCSB PDB) DTXSID0042668 Interactive image O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)Key:XRASPMIURGNCCH-U​​​‍​​‍​​​​‍​​‍‍HFFFAOYSA-N Zoledronic acid, also known aszoledronateand sold under the brand nameZometaamong others,byNovartisamong others, is amedicationused to treat a number ofbone diseases.These includeosteoporosis,high blood calciumdue tocancer,bone breakdowndue to cancer,Paget's disease of boneandDuchenne muscular dystrophy(DMD). It is given byinjection into a vein. Common side effects includefever,joint pain,high blood pressure, diarrhea, and feeling tired.Serious side effects may includekidney problems,low blood calcium, andosteonecrosis of the jaw.Use duringpregnancymay result in harm to the baby.It is in thebisphosphonatefamily of medications.It works by blocking the activity ofosteoclast cellsand thus decreases the breakdown of bone. Zoledronic acid was patented in 1986 and approved for medical use in the United States in 2001.It is on theWorld Health Organization's List of Essential Medicines.