HYDROCORTISONE

USDailyMed:Hydrocortisone AU:A A01AC03(WHO)A07EA02(WHO),C05AA01(WHO),D07AA02(WHO),D07XA01(WHO),H02AB09(WHO),S01BA02(WHO),S01CB03(WHO),S02BA01(WHO) AU:S4(Prescription only) / S3 / S2UK:POM(Prescription only) / P / GSLUS:OTC/ Rx-onlyEU:OTC / Rx-only (8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 50-23-7Y 5754 DB00741Y 5551Y WI4X0X7BPJ D00088YD00165Y CHEBI:17650Y ChEMBL389621Y Interactive image O=C4\C=C2/[C@]([C@H]1[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@H]3[C@@H]1CC2)C)(C)CC4 InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(‍​‍‍‍​‍‍‍‍‍‍‍‍​‍26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1YKey:JYGXADMDTFJGBT-VWUMJDOOSA-NY Hydrocortisoneis the name for the hormonecortisolwhen supplied as a medication.It is acorticosteroidand works as ananti-inflammatoryand byimmune suppression.Uses include conditions such asadrenocortical insufficiency,adrenogenital syndrome,high blood calcium,thyroiditis,rheumatoid arthritis,dermatitis,asthma, andCOPD.It is the treatment of choice for adrenocortical insufficiency.It can be givenby mouth,topically,rectallyor byinjection.Stopping treatment after long-term use should be done slowly. Common side effects may include mood changes,increased appetite,hyperglycemia,hypertension, andedema(swelling).With long-term use, common side effects includeosteoporosis, adrenal insufficiency,upset stomach,physical weakness, easybruising, andcandidiasis(yeast infections).It is unclear if it is safe for use duringpregnancy. Hydrocortisone was patented in 1936 and approved for medical use in 1941.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the 182nd most commonly prescribed medication in the United States, with more than 2million prescriptions.