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USDailyMed:Clotrimazole AU:A A01AB18(WHO)D01AC01(WHO)G01AF02(WHO)QJ02AB90(WHO) CA:OTCUS:OTC(topical), Rx-only (by mouth) 1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole 23593-75-1 2812 2330 DB00257 2710 G07GZ97H65 D00282 CHEBI:3764 ChEMBL104 DTXSID7029871 Interactive image Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17HKey:VNFPBHJOKIVQEB-UHFFFAOYSA-N Clotrimazole, sold under the brand na‍‍‍‍‍‍​​​‍​​​​​​meLotrimin, among others, is anantifungal medication.It is used to treatvaginal yeast infections,oral thrush,diaper rash,tinea versicolor, and types ofringwormincludingathlete's footandjock itch.It is in theazoleclass of medications and works by disrupting the fungalcell membrane.It can be taken by mouth or applied as a cream to the skin or in thevagina. Commonside effectsof clotrimazole taken by mouth include nausea and itchiness.When it is applied to the skin, common side effects include redness and a burning sensation.Inpregnancy, topical use, even in the vagina, is believed to be safe, nor is there evidence of harm by oral use, but the latter has been less well studied. Clotrimazole, originally known as BAYb5097, was discovered in 1969.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the 259th most commonly prescribed medication in the United States, with more than 1million prescriptions.