SPIRONOLACTONE

USDailyMed:Spironolactone AU:B3 C03DA01(WHO) UK:POM(Prescription only)US:℞-onlyEU:Rx-only S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate 52-01-7Y 5833 2875 DB00421Y 5628Y 27O7W4T232 D00443Y CHEBI:9241Y ChEMBL1393Y DTXSID6034186 Interactive image O=C5O[C@@]4([C@@]3([C@H]([C@@H]2[C@H](SC(=O)C)C/C1=C/C(=O)CC[C@]1(C)[C@H]2CC3)CC4)C)CC5 InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1YKey:LXMSZDCAJNLERA-ZHYRCANASA-NY Spironolactone, sold under the brand nameAldactoneamong others, is classed as adiureticmedication.It can be used to treatfluid build-updue toliver diseaseorkidney disease.It is also used to reduce risk of disease progression, hospit‍​‍‍‍​‍‍‍‍‍‍‍‍​‍alization, and death due to some types of heart failure.Other uses include acne and excessive hair growth in women,low blood potassiumthat does not improve withsupplementation, high blood pressure that is difficult to treat, and early puberty in boys.It can also be used to block the effects oftestosteroneas a part offeminizing hormone therapy.Spironolactone is usually available in tablets, takenby mouth, though topical forms are also available. Commonside effectsincludeelectrolyte abnormalities, particularlyhigh blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex.In those with liver or kidney problems, extra care should be taken. If taken during pregnancy, some animal studies suggest that spironolactone may affect the development of sex organs in babies.While this has not occurred in the few human studies available,women who are pregnant or considering pregnancy should discuss spironolactone use with their doctor due to the theoretical risk. Spironolactone is asteroidthatblocksthe effects of thehormonesaldosterone, and to a lesser degree, testosterone, causing someestrogen-like effects.[unreliable source?][unreliable medical source?]Spironolactone belongs to a class of medications known aspotassium-sparing diuretics. Spironolactone was discovered in 1957, and was introduced in 1959.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the 52nd most commonly prescribed medication in the United States, with more than 12million prescriptions.Spironolactone has a history of use in the trans community.Its use continues despite the rise of various accessible alternatives such asbicalutamideandcyproterone acetatewith more precise action and fewer side effects.