MIRTAZAPINE

USDailyMed:Mirtazapine AU:B3 N06AX11(WHO) AU:S4(Prescription only)BR:Class C1(Other controlled substances)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only (±)-5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene 85650-52-8Y 4205 7241 DB00370Y 4060Y A051Q2099Q D00563Y CHEBI:6950Y ChEMBL654Y DTXSID0023325 Interactive image n1cccc3c1N4C(c2ccccc2C3)CN(C)CC4 InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3YKey:RONZAEMNMFQXRA-UHFFFAOYSA-NY Mirtazapine, sold under the brand nameRemeronamong others, is anatypicaltetracyc‍‍‍‍‍‍​​​‍​​​​​​lic antidepressant, and as such is used primarily to treatdepression.Its effects may take up to four weeks but can also manifest as early as one to two weeks.It is often used in cases of depression complicated byanxietyorinsomnia.The effectiveness of mirtazapine is comparable to other commonly prescribed antidepressants.It is takenby mouth. Common side effects includesleepiness,dizziness,increased appetite, andweight gain.Serious side effects may includemania,low white blood cell count, and increasedsuicideamong children.Withdrawalsymptoms may occur when stopping.It is not recommended together with amonoamine oxidase inhibitor,although evidence supporting the danger of this combination has been challenged.It is unclear if use duringpregnancyis safe.How it works is not clear, but it may involveblockingcertainadrenergicandserotonin receptors.Chemically, it is atetracyclic antidepressant,and is closely related tomianserin. It also has strongantihistaminergiceffects. Mirtazapine came into medical use in the United States in 1996.The patent expired in 2004, andgenericversions are available.In 2023, it was the 99th most commonly prescribed medication in the United States, with more than 6million prescriptions.