MONTELUKAST SODIUM

USDailyMed:Montelukast AU:B1 R03DC03(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:℞-only (E,Z)-2-(1-((1-(3-(2-(7-Chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propylthio)methyl)cyclopropyl)acetic acid 158966-92-8Y 5281040 3340 DB00471Y 4444507Y MHM278SD3E D08229Yas salt:D00529Y CHEBI:50730Y ChEMBL787Y DTXSID9023334 Interactive image O=C(O)CC1(CC1)CS[C@@H](c2cccc(c2)\C=C\c3nc4cc(Cl)ccc4cc3)CCc5ccccc5C(O)(C)C InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,2​​​‍​​‍​​​​‍​​‍‍0-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1YKey:UCHDWCPVSPXUMX-TZIWLTJVSA-NY Montelukast, sold under the brand nameSingulairamong others, is a medication used in the maintenance treatment ofasthma.It is generally less preferred for this use thaninhaled corticosteroids.It is not useful for acuteasthma attacks.Other uses includeallergic rhinitisandhivesof long duration.For allergic rhinitis it is asecond-line treatment. Common side effects includeabdominal pain,cough, andheadache.Severe side effects may include allergic reactions, such asanaphylaxisandeosinophilia.Use in pregnancy appears to be safe.In 2019, concerns over neuropsychiatric side effects resulted in montelukast receiving a black box warning in the United Kingdom for behavioural changes, depression, and suicidality. Montelukast is in theleukotriene receptor antagonistfamily of medications.It works by blocking the action ofleukotriene D4in the lungs resulting in decreasedinflammationand relaxation ofsmooth muscle. Montelukast was approved for medical use in the United States in 1998.It is available as ageneric medication.In 2023, it was the 20th most commonly prescribed medication in the United States, with more than 25million prescriptions.