What is MIDAZOLAM HYDROCHLORIDE used for?

Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, in alcohol- or other drug-dependent individuals or those withcomorbidpsychiatric disorders.Additional caution is required in critically ill patients, as accumulation of midazolam and its active metabolites may occur.Kidney or liver impairments may slow down the elimination of midazolam leading to prolonged and enhanced effects.

What pharmaceutical form is MIDAZOLAM HYDROCHLORIDE available in?

MIDAZOLAM HYDROCHLORIDE: SYRUP 2 mg/mL (ORAL)

What are the side effects of MIDAZOLAM HYDROCHLORIDE?

Side effects of midazolam in the elderly are listed above.People experiencingamnesiaas a side effect of midazolam are generally unaware their memory is impaired, unless they had previously known it as a side effect. Long-term use of benzodiazepines has been associated with long-lasting deficits in memory, and show only partial recovery six months after stopping benzodiazepines.It is unclear whether full recovery occurs after longer periods of abstinence. Benzodiazepines can cause or worsen depre

Does MIDAZOLAM HYDROCHLORIDE interact with other medications?

Protease inhibitors,nefazodone,sertraline,grapefruit,fluoxetine,erythromycin,diltiazem, andclarithromycininhibit the metabolism of midazolam, leading to a prolonged action.St John's wort,rifapentine,rifampin,rifabutin, andphenytoinenhance the metabolism of midazolam leading to a reduced action. Sedating antidepressants, antiepileptic drugs (e.g.,phenobarbital, phenytoin, andcarbamazepine),first-generation antihistamines,opioids,antipsychotics, andalcoholenhance the sedative effects of midazolam.

Can MIDAZOLAM HYDROCHLORIDE be used during pregnancy?

Midazolam, when taken during thethird trimesterof pregnancy, may cause risk to the neonate, including benzodiazepine withdrawal syndrome, with possible symptoms includinghypotonia,apnoeicspells,cyanosis, and impairedmetabolicresponses to cold stress. Symptoms of hypotonia and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth.Otherneonatal withdrawalsymptoms include hyperexcitability, tremor, and gastrointestinal upset (diarrhea or vomi

What ATC class does MIDAZOLAM HYDROCHLORIDE belong to?

MIDAZOLAM HYDROCHLORIDE: ATC N05CD08. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

MIDAZOLAM HYDROCHLORIDE

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

USDailyMed:Midazolam AU:C N05CD08(WHO) AU:S4(Prescription only)BR:Class B1(Psychoactive drugs)CA:Schedule IVDE: Prescription only (Anlage IIIfor higher doses)NZ:Class CUK:POM(Prescription only)US:Schedule IVEU:Rx-only 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 59467-70-8Y 4192 3342 DB00683Y 4047Y R60L0SM5BC D00550Yas HCl:D00696Y CHEBI:6931 ChEMBL655Y DTXSID5023320 Interactive image ClC1=CC=C2C(C(C3=CC=CC=C3F)=NCC4=CN=C(C)N42)=C1 InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3YKey:DDLIGBOFAVUZHB-UHFFFAOYSA-NY Midazolam, sold under the brand nameVersedamong others, is abenzodiazepinemedication used foranesthesia,premedicationbefore surgical anesthesia, andprocedural sedation, and to treatsevere agitation.It induces sleepiness, decreases anxiety, and causesanterograde amnesia. The drug does not cause an individual to become unconscious, merely to be sedated.It is also useful for the treatment of prolonged (lasting over five minutes)seizures.Midazolam can be givenby mouth,intravenously, byinjection into a muscle, by spraying into thenose, or through thecheek.When given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working;when taken orally, it can take 10–20 minutes to begin working. Side effects can include a decrease in efforts to breathe,low blood pressure, and sleepiness.Toleranceto its effects andwithdrawal syndromemay occur following long-term use.Paradoxical effects, such as increased activity, can occur especially in children and older people.There is evidence of risk when used during pregnancy but no evidence of harm with a single dose duringbreastfeeding. Midazolam was patented in 1974 and came into medical use in 1982.It is on theWorld Health Organization's List of Essential Medicines.Midazolam is available as ageneric medication.In many countries, it is acontrolled substance.

MIDAZOLAM HYDROCHLORIDE

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