What are the side effects of Norethindrone - Indications, Dosage, Side Effects and Precautions?

Most Common - Headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss. Genitourinary - Change in sexual interest, changes in menstrual flow, changes in cervical mucus secretion. Central Nervous System - Headache, dizziness, mood swings, trouble sleeping. Heart - High blood pressure Liver - Abnormal liver tests, jaundice. Eye - Blurred/double vision, loss of vision. Skin - Hives, rash, acne, growth o

Does Norethindrone - Indications, Dosage, Side Effects and Precautions interact with other medications?

5α-Reductaseplays an important role in themetabolismof norethisterone, and5α-reductase inhibitorssuch asfinasterideanddutasteridecan inhibit its metabolism.Norethisterone is partially metabolized viahydroxylationbyCYP3A4, andinhibitorsandinducersof CYP3A4 can significantly alter circulating levels of norethisterone.For instance, the CYP3A4 inducersrifampicinandbosentanhave been found to decrease norethisterone exposure by 42% and 23%, respectively, and the CYP3A4 inducerscarbam

What precautions should be taken with Norethindrone - Indications, Dosage, Side Effects and Precautions?

•Caution needed for patients with history of high blood pressure, heart disease, liver impairment, epilepsy, breastfeeding, new onset of migraine-type headache, asthma, kidney impairment, history of clinical depression.

Norethindrone - Indications, Dosage, Side Effects and Precautions — Description, Dosage, Side Effects

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

USDailyMed:Norethindrone G03AC01(WHO)G03DC02(WHO) CA:℞-onlyUS:℞-only (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one 68-22-4Y 6230 2880 DB00717Y 5994Y T18F433X4S D00182Y CHEBI:7627Y ChEMBL1162Y DTXSID9023380 Interactive image C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34 InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1YKey:VIKNJXKGJWUCNN-XGXHKTLJSA-NY Norethisterone, also known asnorethindroneand sold under the brand nameNorlutinamong others, is aprogestinmedication used inbirth control pi‍‍‍‍‍‍‍lls,menopausal hormone therapy, and for the treatment ofgynecological disorders.The medication is available in both low-dose and high-dose formulations and both alone and in combination with anestrogen.It is usedby mouthor, asnorethisterone enanthate, byinjection into muscle. Side effectsof norethisterone includemenstrual irregularities,headaches,nausea,breast tenderness,moodchanges,acne,increased hair growth.Norethisterone is a progestin, or asyntheticprogestogen, and hence is anagonistof theprogesterone receptor, thebiological targetof progestogens likeprogesterone.It has weakandrogenicandestrogenicactivity, mostly at high dosages, and no other importanthormonalactivity. Norethisterone was discovered in 1951 and was one of the first progestins to be developed.It was first introduced for medical use on its own in 1957 and was introduced in combination with an estrogen for use as a birth control pill in 1963.It is sometimes referred to as a "first-generation" progestin.LikedesogestrelandNorgestrel, Norethisterone is available as aprogestogen-only "mini pill"for birth control.Norethisterone is marketed widely throughout the world.It is available as ageneric medication.In 2023, it was the 136th most commonly prescribed medication in the United States, with more than 4million prescriptions.It is on theWorld Health Organization's List of Essential Medicines.

Norethindrone - Indications, Dosage, Side Effects and Precautions

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