BONINE

USDailyMed:Meclizine R06AE05(WHO) AU:S4(Prescription only)CA:OTCUS:OTC (RS)-1-[(4-chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine 569-65-3Y 4034 2757 DB00737N 3894Y 3L5TQ84570 D08163D01317 ChEMBL1623N DTXSID0023242 Interactive image Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)Cc4cccc(c4)C InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2‍‍‍‍‍‍​​​‍​​​​​​-13,18,25H,14-17,19H2,1H3YKey:OCJYIGYOJCODJL-UHFFFAOYSA-NY Meclizine, sold under the brand nameBonine, among others, is anantihistamineused to treatmotion sicknessand dizziness (vertigo).It is taken by mouth.Effects generally begin in an hour and last for up to a day. Common side effects include sleepiness and dry mouth.Serious side effects may includeallergic reactions.Use inpregnancyappears safe, but has not been well studied; use inbreastfeedingis of unclear safety.It is believed to work in part byanticholinergicandantihistaminemechanisms. Meclizine was patented in 1951 and came into medical use in 1953.It is available as ageneric medicationand oftenover the counter.In 2023, it was the 137th most commonly prescribed medication in the United States, with more than 4million prescriptions.