OMEPRAZOLE; SODIUM BICARBONATE

USDailyMed:Omeprazole AU:B3 A02BC01(WHO)A02BC51(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:OTC/ Rx-onlyEU:Rx-only 5-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-benzimidazole 73590-58-6Y 4594 4279 DB00338Y 4433Y KG60484QX9 D00455Y CHEBI:7772Y ChEMBL1503Y 1C6 (PDBe,RCSB PDB) DTXSID6021080 Interactive image CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)YKey:SUBDBMMJDZJVOS-UHFFFAOYSA-NY Omeprazole, sold under the brand namesPrilosecandLosecamong ​‍​​​​​‍​‍‍‍‍​‍‍others, is a medication used in the treatment ofgastroesophageal reflux disease(GERD),peptic ulcer disease, andZollinger–Ellison syndrome.It is also used to preventupper gastrointestinal bleedingin people who are at high risk.Omeprazole is aproton-pump inhibitor(PPI) and its effectiveness is similar to that of other PPIs.It can be taken by mouth or byinjection into a vein.It is also available in the fixed-dosecombination medicationomeprazole/sodium bicarbonate as Zegeridand as Konvomep. Common side effects include nausea, vomiting, headaches, abdominal pain, andincreased intestinal gas.Serious side effects may includeClostridioides difficilecolitis, an increased risk ofpneumonia, an increased risk ofbone fractures, and the potential of maskingstomach cancer.Whether it is safe for use inpregnancyis unclear.It works by blocking the release ofstomach acid. Omeprazole was patented in 1978 and approved for medical use in 1988.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the tenth most commonly prescribed medication in the United States, with more than 45million prescriptions.It is also available without a prescription in the United States.