Tadalafil

USDailyMed:Tadalafil AU:B1 G04BE08(WHO) AU:S4(Prescription only)UK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only) (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione 171596-29-5Y 110635 7299 DB00820Y 99301Y 742SXX0ICT D02008Y CHEBI:71940Y ChEMBL779Y CIA (PDBe,RCSB PDB) DTXSID9046786 Interactive image CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3c(c2)OCO3)C1=O InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1YKey:WOXKDUGGOYFFRN-IIBYNOLFSA-NY Tadalafil, sold under the brand nameCialisamong others, is amedicationused to treaterectile dysfunction,benign prostatic hyperplasia, andpulmonary arterial hypertension.It is takenby mouth.Onset is typically within half an hour and the duration is up to 36 hours. Common side effects include headache, muscle pain,flushing, and nausea.Caution is advised in those withcardiovascular disease.Rare but serious side effects include aprolonged erectionthat can lead to damage to thepenis, vision problems, andhearing loss.Tadalafil is not recommended in people takingnitrovasodilatorssuch asnitroglycerin, as this may result in a serious drop inblood pressure.Tadalafil is aPDE5 inhibitorwhich increases blood flow to the penis.It also dilatesblood vesselsin the lungs, which lowers thepulmonary arterypressure. Tadalafil was approved for medical use in the United States in 2003.It is available as ageneric medication.In 2022, it was the 172nd most commonly prescribed medication in the United States, with more than 3million prescriptions.