Dapsone

USDailyMed:Dapsone D10AX05(WHO)J04BA02(WHO) AU:S4(Prescription only)US:℞-onlyIn general: ℞ (Prescription only) 4-[(4-aminobenzene)sulfonyl]aniline 80-08-0Y 2955 DB00250Y 2849Y 8W5C518302 D00592Y CHEBI:4325Y ChEMBL1043Y DTXSID4020371 Interactive image O=S(=O)(c1ccc(N)cc1)c2ccc(N)cc2 InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2YKey:MQJKPEGWNLWLTK-UHFFFAOYSA-NY Dapsone, also known as4,4'-sulfonyldianiline(SDA) ordiaminodiphenyl sulfone(DDS),is anantibioticcommonly used in combination withrifampicinandclofaziminefor the treatment ofleprosy.It is a second-line medication for the treatment and prevention ofpneumocystis pneumoniaand for the prevention oftoxoplasmosisin those who havepoor immune function.Additionally, it has been used foracne,dermatitis herpetiformis, and various other skin conditions.Dapsone is available both topically and by mouth. Severe side effects may include adecrease in blood cells,red blood cell breakdownespecially in those withglucose-6-phosphate dehydrogenase deficiency(G-6-PD), or hypersensitivity.Common side effects include nausea and loss of appetite.Other side effects includeliver inflammation,methemoglobinemia,and a number of types of skin rashes.While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy.It is of thesulfoneclass. Dapsone was first studied as an antibiotic in 1937.Its use for leprosy began in 1945.It is on theWorld Health Organization's List of Essential Medicines.The form, which is taken by mouth, is available as ageneric drugand not very expensive.