Pharmacotherapeutic group: Beta Blocker agents; Beta blocker agents, selective, ATC code: C07AB04.
Mode of action: Acebutolol is a beta adrenoceptor antagonist which is cardio selective, i.e. acts preferentially on beta1 adrenergic receptors in the heart. Its principal effects are to reduce heart rate especially on exercise and to lower blood pressure in hypertensive subjects. Acebutolol and its active metabolite, diacetolol have antiarrhythmic activity, the combined plasma half-life of the active drug and metabolite being 7-10 hours. Both have partial agonist activity (PAA) also known as intrinsic sympathomimetic activity (ISA). This property ensures that some degree of stimulation of beta receptors is maintained. Under conditions of rest, this tends to balance the negative chronotropic and negative inotropic effects. Acebutolol blocks the effects of excessive catecholamine stimulation resulting from stress.
⚠️ Warnings
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
