Pharmacotherapeutic group: Blood substitutes and perfusion solutions, i.v. solutions for parenteral nutrition, amino acids, ATC code: B05B A01
Mechanism of action
The aim of parenteral nutrition is the supply of all nutrients necessary for the growth, maintenance and regeneration of body tissues etc.
Amino acids are of special importance as they partly are essential for protein synthesis. Intravenously administered amino acids are incorporated in the respective intravascular and intracellular amino acid pools. Both endogenous and exogenous amino acids serve as substrate for the synthesis of functional and structural proteins.
To prevent the metabolisation of amino acids for energy production, and also to fuel the other energy-consuming processes in the organism, simultaneous non-protein energy supply (in the form of carbohydrates or fats) is necessary.
⚠️ Warnings
No special requirements for disposal.
Containers are for single use only. Discard container and any unused contents after use.
The solution should only be used if the closure of the container is not damaged and if the solution is clear colourless to faintly straw-coloured, practically free from visible particles.
Use a sterile giving set for administration.
If in the setting of complete parenteral nutrition it is necessary to add other nutrients such as carbohydrates, lipids, vitamins, electrolytes and trace elements to this medicinal product, admixing must be performed under strict aseptic conditions. Mix well after admixture of any additive. Pay special attention to compatibility.
- Glucose: physicochemical stability has been demonstrated for 24 hours at room temperature up to a total quantity of 158 g/l of glucose in the mixture.
- Electrolytes: physicochemical stability has been demonstrated for 24 hours at room temperature up to a total quantity of 32 mmol/l of sodium, 16 mmol/l potassium and 2 mmol/l of magnesium in the mixture.
- Lipids: physicochemical stability has been demonstrated for 24 hours at room temperature up to a total quantity of 50 g/l of lipid emulsion in the mixture.
- Trace elements and vitamins: stability has been demonstrated for 24 hours at room temperature with commercially available multi-trace elements and multi-vitamins (e.g. Tracutil, Cernevit) up to the standard dosage recommended by the respective manufacturer of the micronutrient.
PillsCard reference image