Bupivacaine - Indications, Dosage, Side Effects and Precautions

USDailyMed:Bupivacaine AU:A N01BB01(WHO) AU:S4(Prescription only)US:℞-onlyEU:Rx-only (RS)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide 38396-39-3YHCl:73360-54-0Y 2474HCl:5282419 2397 DB00297Y 2380YHCl:58277 Y8335394ROHCl:7TQO7W3VT8 D07552YHCl:D01450 CHEBI:60789NHCl:CHEBI:31322 ChEMBL1098YHCl:ChEMBL1200396 DTXSID2022703 Interactive image O=C(C1N(CCCC1)CCCC)NC2=C(C)C=CC=C2C InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)YKey:LEBVLXFERQHONN-UHFFFAOYSA-N‍‍‍‍‍‍​​​‍​​​​​​Y Bupivacaine, sold under the brand nameMarcaineamong others, is a medication used todecrease sensation in a specific small area.Innerve blocks, it is injected around a nerve that supplies the area, or into thespinal canal's epidural space.It is available mixed with a small amount ofepinephrineto increase the duration of its action.It typically begins working within 15 minutes and lasts for 2 to 8 hours. Possible side effects include sleepiness, muscle twitching,ringing in the ears, changes in vision,low blood pressure, and an irregular heart rate.Concerns exist that injecting it into a joint can cause problems with thecartilage.Concentrated bupivacaine is not recommended for epidural freezing.Epidural freezing may also increase the length oflabor.It is alocal anaestheticof theamide group. Bupivacaine was discovered in 1957.It is on theWorld Health Organization's List of Essential Medicines.Bupivacaine is available as ageneric medication.Animplantable formulationof bupivacaine (Xaracoll) was approved for medical use in the United States in August 2020.