Pharmacotherapeutic Group: Other antifungals for topical use ATC code: D01AE16
Amorolfine 5% w/v Medicated nail lacquer is a topical antimycotic. Amorolfine belongs to a new chemical class, and its fungicidal action is based on an alteration of the fungal cell membrane targeted primarily on sterol biosynthesis. The ergosterol content is reduced, and at the same time unusual sterically nonplanar sterols accumulate.
Amorolfine is a broad spectrum antimycotic. It is highly active (MIC < 2mcg/ml)
in vitro
against
yeasts:
Candida, Cryptococcus, Malassezia
dermatophytes:
Trichophyton, Microsporum, Epidermophyton
moulds:
Hendersonula, Alternaria, Scopulariopsis
dematiacea:
Cladosporium, Fonsecaea, Wangiella
dimorphic fungi:
Coccidioides, Histoplasma, Sporothrix
With the exception of
Actinomyces
, bacteria are not sensitive to amorolfine.
Propionibacterium acnes
is only slightly sensitive.
⚠️ Warnings
No special instructions.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
