What is Xaluprine used for?

Mercaptopurine monohydrate is indicated for the treatment of acute leukaemia in adults, adolescents and children. It may be utilised in: - Acute lymphoblastic leukaemia (ALL); - Acute promyelocytic leukaemia (APL)/Acute myeloid leukaemia M3 (AML M3)).

How does Xaluprine work?

Pharmacotherapeutic group: antineoplastic agents, antimetabolites, purine analogues, ATC Code: L01BB02 Mechanism of action Mercaptopurine monohydrate is sulphydryl analogue of the purine bases, adenine and hypoxanthine and acts as a cytotoxic antimetabolite.

What is the active ingredient in Xaluprine?

Mercaptopurinum (Mercaptopurinum)

What pharmaceutical form is Xaluprine available in?

Xaluprine: Zawiesina doustna 20 mg/ml (doustna)

What are the side effects of Xaluprine?

Summary of the safety profile The main side effect of treatment with mercaptopurine monohydrate is bone marrow suppression leading to leucopenia and thrombocytopenia. For mercaptopurine monohydrate there is a lack of modern clinical documentation which can serve as support for accurately determining the frequency of undesirable effects. The frequency categories assigned to the adverse drug reactions below are estimates for most reactions, suitable data for calculating incidence

Who should NOT take Xaluprine?

Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Concomitant use with yellow fever vaccine (see section 4.5).

Does Xaluprine interact with other medications?

The administration of mercaptopurine monohydrate with food may decrease systemic exposure slightly. Mercaptopurine monohydrate may be taken with food or on an empty stomach, but patients should standardise the method of administration to avoid large variability in exposure. The dose should not be taken with milk or dairy products since they contain xanthine oxidase, an enzyme which metabolises 6–mercaptopurine and might therefore lead to reduced plasma concentrations of mercapt

Can Xaluprine be used during pregnancy?

Contraception in males and females Evidence of the teratogenicity of mercaptopurine monohydrate in humans is equivocal. Both sexually active men and women should use effective methods of contraception during treatment and for at least three months after receiving the last dose. Animal studies indicate embryotoxic and embryolethal effects (see section 5.3). Pregnancy Mercaptopurine monohydrate should not be given to patients who are pregnant or likely to become pregnant without

What precautions should be taken with Xaluprine?

Safe handling : It is recommended that mercaptopurine monohydratef tablets should be handled following the prevailing local recommendations and/or regulations for the handling and disposal of cytotoxic agents. Anyone handling Mercaptopurine should wash their hands before and after administering a dose. To decrease the risk of exposure, parents and care givers should wear disposable gloves when handling Mercaptopurine. Mercaptopurine contact with skin or mucous membrane must be

Who manufactures Xaluprine?

Nova Laboratories Ireland Limited (Irlandia)

What ATC class does Xaluprine belong to?

Xaluprine: ATC L01BB02. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

OTC

Xaluprine

20 mg/ml, Zawiesina doustna

INN: Mercaptopurinum

Data updated: 2026-04-13

Available in:

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Form

Zawiesina doustna

Dosage

20 mg/ml

Route

doustna

Storage

—

About This Product

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