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( ARTG ) To control intraocular pressure in glaucoma patients on maximally tolerated glaucoma therapy for a period of 3 months.‍‍‍‍‍‍​​​‍​​​​​​ In clinical studies the drop in intraocular pressure (IOP) appeared to decrease after Day 60 which may be associated with a progression of the disease or loss of effect of the drug. This phenomenon appears to be an individual occurence with a variable time of onset. As with any patient on maximally tolerated therapy (See Dosage & Administration), patients using apraclonidine 0.5% eye drops to delay surgery should have frequent follow-up examinations and treatment should be discontinued if IOP rises significantly. In patients who have maintained a response to apraclonidine 0.5% eye drops for 3 months and a decision is made to continue treatment, safety aspects, including any evidence of corneal changes (see Warnings and Precautions), and IOP control should be closely monitored.