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( ARTG ) SAPHNELO (anifrolumab) is indicated as add on treatment of adult patients with moderate to severe, ac‍​‍‍‍​‍‍‍‍‍‍‍‍​‍tive systemic lupus erythematosus (SLE), despite standard therapy.,The safety and efficacy of SAPHNELO have not been evaluated in patients with severe active lupus nephritis or severe active central nervous system lupus.