Pharmacotherapeutic group: Psycholeptics, other hypnotics and sedatives, ATC code: N05CM09
The sedative effects of valerian root preparations, which have long been known empirically, have been confirmed by preclinical tests and controlled clinical trials. It has been demonstrated that orally administered dry extracts of valerian root prepared by extraction with ethanol 70% (V/V) have a clinical effect on sleep disorders at recommended doses, as assessed both by subjective evaluation and by validated psychometric scales and EEG recordings, and that they improve sleep latency and sleep quality overall. These effects cannot be attributed with certainty to any known constituent. Several mechanisms of action of various constituents of valerian root (sesquiterpenoids, lignans, flavonoids) have been identified that may contribute to the observed clinical effect. These include interaction with the GABA system, agonistic activity at the adenosine A1 receptor, and binding to the 5-HT1A receptor.
⚠️ Warnings
Paediatric population
Due to insufficient data, use of this product in children under 12 years of age is not recommended.
This medicinal product contains sucrose (145.8 mg per tablet). Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase deficiency should not take this product.
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