This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.
OTC
Amaryl P 15 mg/2 mg Tablet
INN: PIOGLITAZONE
Data updated: 2026-06-02
Available in:
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About This Product
ATC Code
A10BG03
Source
AIFA
USDailyMed:Pioglitazone
AU:B3
A10BG03(WHO)
AU:S4(Prescription only)UK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only)
(RS)-5-(4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl)thiazolidine-2,4-dione
111025-46-8Y
4829
2694
DB01132Y
4663Y
X4OV71U42S
D08378Yas HCl:D00945Y
CHEBI:8228Y
ChEMBL595Y
DTXSID3037129
Interactive image
O=C1NC(=O)SC1Cc3ccc(OCCc2ncc(cc2)CC)cc3
InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)YKey:HYAFETHFCAUJAY-UHFFFAOYSA-NY
Pioglitazone, sold under the brand nameActosamong others, is ananti-diabetic medicationused to treattype 2 diabetes.It may be used withmetformin, asulfonylurea, orinsulin.Use is recommended together with exercise and diet.It is not recommended intype 1 diabetes.It is takenby mouth.
Common side effects include headaches, muscle pains, inflammation of the throat, and swelling.Serious side effects may includebladder cancer,low blood sugar,heart failure, andosteoporosis.Use is not recommended inpregnancyorbreastfeeding.It is in thethiazolidinedione(TZD) class and works by improving sensitivity of tissues to insulin.
Pioglitazone was patented in 1985, and came into medical use in 1999.It is available as ageneric medication.In 2023, it was the 133rd most commonly prescribed medication in the United States, with more than 4million prescriptions.It was withdrawn in France and Germany in 2011.
Warnings
•Proper diet, regular exercise, and regular blood sugar testing are important for best results of this medication. Follow the diet and exercise program given to you by your health care provider.
• Caution should be exercised in patients with history of liver, heart, diabetic eye diseases, and polycystic ovary syndrome.
• Increased risk of low blood sugar when used with insulin or oral hypoglycemic.
• It may lead to edema, congestive heart failure, liver dysfunction, jaundice, and anemia.
• It may cause ovulation in premenopausal, anovulatory women.
• Monitor liver function before and during treatment, glucose control.
• Stop treatment if alanine transaminase, a liver enzyme increases and remains >3 times above the upper limit of normal or if jaundice develops.
Verified by medical editor
Kseniia Ozarchuk, MPharm · April 2026
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