PRENISONE TABLETS

USDailyMed:Methylprednisolone AU:A D07AA01(WHO)D07AC14(WHO),D10AA02(WHO),H02AB04(WHO),D07CA02(WHO),S01CA08(WHO),H02BX01(WHO),S03CA07(WHO) CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only (1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one 83-43-2Y 6741 7088 DB00959Y 6485Y X4W7ZR7023 D00407Y CHEBI:6888Y ChEMBL650Y DTXSID7023300 Interactive image O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](C)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)CC[C@@H]23)C)C InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1YKey:VHRSUDSXCMQTMA-PJHHCJLFSA-NY Methylprednisolone, sold under the brand nameMedrolamong others, is a syntheticglucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects.It is either used at low doses for chronic illnesses or used at high doses during acute flares.‍​‍‍‍​‍‍‍‍‍‍‍‍​‍ Methylprednisolone and its derivatives can be administered orally orparenterally. Regardless of the route of administration, methylprednisolone integrates systemically as exhibited by its effectiveness to quickly reduce inflammation during acute flares.It is associated with many adverse reactions that requiretapering offthe drug as soon as the disease is under control.Serious side effects include iatrogenicCushing's syndrome, hypertension, osteoporosis, diabetes, infection, psychosis, and skin atrophy. Chemically, methylprednisolone is a syntheticpregnanesteroid hormonederived fromhydrocortisoneandprednisolone. It belongs to a class of synthetic glucocorticoids and more generally,corticosteroids. It acts as a mineralocorticoid and glucocorticoid receptor agonist. In comparison to other exogenous glucocorticoids, methylprednisolone has a higher affinity to glucocorticoid receptors than to mineralocorticoid receptors. Glucocorticoid's name was derived after the discovery of their involvement in regulating carbohydrate metabolism.The cellular functions of glucocorticoids, such as methylprednisolone, are now understood to regulate homeostasis, metabolism, development, cognition, and inflammation.They play a critical role in adapting and responding to environmental, physical, and emotional stress. Methylprednisolone was first synthesized and manufactured byThe Upjohn Company(nowViatris) and approved for use by theFood and Drug Administration(FDA) in the United States in October 1957.In 2023, it was the 135th most commonly prescribed medication in the United States, with more than 4 million prescriptions.It is on theWorld Health Organization's List of Essential Medicines.