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( ARTG ) Congestive heart failure; Lanoxin is useful regardless of whether the failure is predominantly of the left or right ventricle, or involves both sides of the heart.‍​‍‍‍​‍‍‍‍‍‍‍‍​‍ It is particularly useful in heart failure resulting from chronic overload (hypertension, valvular lesions, atherosclerotic heart disease) in which the supply of energy is not impaired. Lanoxin does not cause major benefit in situations in which the metabolic energy supply is compromised as in thyrotoxicosis, hypoxia, and severe thiamine deficiency. Atrial fibrillation: Because Lanoxin depresses conduction in the atrioventricular bundle, producing a slower ventricular beat, it is valuable in atrial fibrillation. It will frequently convert atrial flutter into fibrillation and, upon withdrawal of the drug, normal sinus rhythm may be restored. Paroxysmal atrial tachycardia: Lanoxin may relieve or prevent an attack, but its use in paroxysmal ventricular tachycardia is dangerous.