Atorvastatin

USDailyMed:Atorvastatin AU:DContraindicated C10AA05(WHO)C10BX08(WHO)C10BX03(WHO)C10BA05(WHO)C10BA08(WHO)C10BX15(WHO)C10BX12(WHO)C10BX06(WHO)C10BX11(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only (3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid 134523-00-5Y 60823 2949 APRD00055N 54810Y A0JWA85V8F D07474Y CHEBI:39548Y ChEMBL1487Y 117 (PDBe,RCSB PDB) DTXSID8029868 Interactive image O=C(O)C[C@H](O)C[C@H](O)CCn2c(c(c(c2c1ccc(F)cc1)c3ccccc3)C(=O)Nc4ccccc4)C(C)C InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1YKey:XUKUURHRXDUEBC-KAYWLYCHSA-NY Atorvastatin, sold under the brand nameLipitoramong others, is astatinmedication used to preventcardiovascular diseasein those at high risk and to treatabnormal lipid levels.For the prevention of cardiovascular disease, statins are a first-line treatment in reducing cholesterol.It is takenby mouth. Common side effects may include diarrhea, heartburn, nausea, muscle pain (typically mild and dose-dependent) and, less frequently, joint pain. Muscle symptoms often occur during the first year and are commonly influenced by pre-existing health issues and thenoceboeffect.Most patients can continue therapy with dose adjustment or statin switching. Rare (<0.1%) but serious side effects may include rhabdomyolysis (severe muscle disorder), liver problems and diabetes.Use duringpregnancymay harm thefetus.Like all statins, atorvastatin works by inhibitingHMG-CoA reductase, anenzymefound in theliverthat plays a role in producingcholesterol. Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the most commonly prescribed medication in the United States, with more than 115million prescriptions filled for over 29 million people.In Australia, in 2023, it was the second most prescribed medication afterRosuvastatin.