CHOLECALCIFEROL#CHOLECALCIFEROL

USDailyMed:Cholecalciferol A11CC05(WHO) CA:℞-onlyUS:OTC (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol 67-97-0 5280795 DB00169 4444353 1C6V77QF41 C05443 CHEBI:28940 ChEMBL1042 DTXSID6026294 Interactive image O[C@@H]1CC(\C(=C)CC1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CCCC(C)C)C InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1NKey:QYSXJUFSXHHAJI-YRZJJWOYSA-N Cholecalciferol, also known asvitamin D3,colecalciferolorcalciol, is a skin-madevitamin Dthat is found in certain foods and used as adietary supplement.It was first described in 1936,and is on‍‍‍‍‍‍​​​‍​​​​​​ theWorld Health Organization's List of Essential Medicines.In 2023, it was the 68th most commonly prescribed medication in the United States, with more than 9million prescriptions,and is available as ageneric medication. Cholecalciferol is synthesised in the skin following sunlight exposure.It is then converted in the liver tocalcifediol(25-hydroxycholecalciferol D), which is further converted in the kidney tocalcitriol(1,25-dihydroxycholecalciferol D).One of calcitriol's most important functions is to promotecalciumuptake by the intestines.Cholecalciferol is present in food such as fatty fish, beef liver, eggs, and cheese.In some countries, cholecalciferol is also added to products like plants, cow milk, fruit juice, yogurt, and margarine. Cholecalciferol can be taken orally as a dietary supplement to preventvitamin D deficiencyor as a medication to treat associated diseases, includingrickets.It is also used in the management offamilial hypophosphatemia,hypoparathyroidismthat is causinglow blood calcium, andFanconi syndrome.Vitamin-D supplements may not be effective in people with severekidney disease.Excessive doses in humans can result in vomiting, constipation, muscle weakness, and confusion.Other risks includekidney stones.Doses greater than40000IU(1000 μg) per day are generally required beforehigh blood calciumoccurs.Normal doses,800–2000IU per day, are safe inpregnancy.