Adefresh 400 Tablet

29908-03-0Y Interactive image ChEMBL1088977N 8041295Y C00019N 9865604 7LP2MPO46SY DTXSID6032019 InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7?,8-,10-,11-,14-,27?/m1/s1YKey: MEFKEPWMEQBLKI-YDBXVIPQSA-OYInChI=1/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7?,8-,10-,11-,14-,27?/m1/s1Key: MEFKEPWMEQBLKI-NNGIMXIKBF O=C(O)C(N)CC[S+](C)C[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3O S-Adenosyl methionine(SAM), also known under the commercial names ofSAMe,SAM-e, orAdoMet, is a commoncosubstrateinvolved inmethyl grouptransfers,transsulfuration, and aminopropylation.‍‍‍‍‍‍​​​‍​​​​​​ Although theseanabolicreactions occur throughout the body, most SAM is produced and consumed in the liver.More than 40 methyl transfers from SAM are known, to various substrates such asnucleic acids,proteins,lipidsandsecondary metabolites. It is made fromadenosine triphosphate(ATP) andmethioninebymethionine adenosyltransferase. SAM was first discovered byGiulio Cantoniin 1952. Inbacteria, SAM is bound by theSAM riboswitch, which regulatesgenesinvolved in methionine orcysteinebiosynthesis. Ineukaryoticcells, SAM serves as a regulator of a variety of processes includingDNA,tRNA, andrRNAmethylation;immune response;amino acid metabolism;transsulfuration; and more. In plants, SAM is crucial to the biosynthesis ofethylene, an importantplant hormoneand signaling molecule. SAMe has been studied fordepression,osteoarthritis, andliver diseaseswith inconclusive results, and while generally considered safe short-term, its long-term safety, use duringpregnancy, and risks for people withbipolar disorderor compromisedimmune systemsremain unclear.