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Manufacturer
KRKA, d.d. Novo Mesto (BG)
ATC Code
N06AX 11
Source
BDA
USDailyMed:Mirtazapine
AU:B3
N06AX11(WHO)
AU:S4(Prescription only)BR:Class C1(Other controlled substances)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only
(±)-5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene
85650-52-8Y
4205
7241
DB00370Y
4060Y
A051Q2099Q
D00563Y
CHEBI:6950Y
ChEMBL654Y
DTXSID0023325
Interactive image
n1cccc3c1N4C(c2ccccc2C3)CN(C)CC4
InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3YKey:RONZAEMNMFQXRA-UHFFFAOYSA-NY
Mirtazapine, sold under the brand nameRemeronamong others, is anatypicaltetracyclic antidepressant, and as such is used primarily to treatdepression.Its effects may take up to four weeks but can also manifest as early as one to two weeks.It is often used in cases of depression complicated byanxietyorinsomnia.The effectiveness of mirtazapine is comparable to other commonly prescribed antidepressants.It is takenby mouth.
Common side effects includesleepiness,dizziness,increased appetite, andweight gain.Serious side effects may includemania,low white blood cell count, and increasedsuicideamong children.Withdrawalsymptoms may occur when stopping.It is not recommended together with amonoamine oxidase inhibitor,although evidence supporting the danger of this combination has been challenged.It is unclear if use duringpregnancyis safe.How it works is not clear, but it may involveblockingcertainadrenergicandserotonin receptors.Chemically, it is atetracyclic antidepressant,and is closely related tomianserin. It also has strongantihistaminergiceffects.
Mirtazapine came into medical use in the United States in 1996.The patent expired in 2004, andgenericversions are available.In 2023, it was the 99th most commonly prescribed medication in the United States, with more than 6million prescriptions.
⚠️ Warnings
•Avoid in unstable cases, epilepsy or history of seizures.
• Caution should be exercised in patients with history of liver or kidney damage, heart diseases, recent sudden heart attack, low blood pressure, diabetes, psychoses, and history of bipolar disorder, elderly, pregnancy and breastfeeding.
Stop treatment if jaundice, urination disturbances, angle-closure glaucoma, raised intraocular pressure develops.
Monitor patient for signs of bone marrow depression and suicidal tendency.
It may cause drowsiness, dizziness or impaired vision, do not drive a car or operate machinery while taking this medication.