Cefepime

•Caution should be exercised in patients with history of penicillin or cephalosporin allergy, gastro intestinal disease, especially colitis; lactation, pregnancy, seizures. It may decrease prothrombin activity; monitor prothrombin time in patients with poor nutritional state, kidney or liver impairment and those on prolonged treatment. Prolonged treatment may result in overgrowth of non-susceptible organisms, resulting in superinfection. Consider the possibility of Clostridium difficile associated diarrhea in patients who present with diarrhea after treatment. ♦ Patient may develop with increased risk of neurotoxicity.