Penicillamine - Indications, Dosage, Side Effects and Precautions

• Wilson's disease and cyst in urine (25 mg/day) continued on a daily basis once instituted; kidney impairment; penicillin allergy; Monitor urine for protein in urine and haematuria (blood in urine), blood and platelet counts regularly. Withdraw permanently if decrease in the num‍‍‍‍‍‍​​​‍​​​​​​ber of white blood cells or platelets occurs. • Regularly monitor kidney and liver function (every 6 month). Monitor body temperature twice weekly during 1st month of therapy, then every 2 wk for 5 month, then monthly. Counsel patient to report sore throat, fever, infection, non-specific illness, unexplained bleeding or bruising, mouth ulcers or rashes. In cyst in urine, maintain adequate fluid intake (1 pint of fluid before bed and 1 pint of fluid during night). • Caution should be exercised in patients who have had previous adverse reactions to gold.