METHIMAZOLE

USDailyMed:Thiamazole H03BB02(WHO) AU:S4(Prescription only)CA:℞-onlyUS:℞-only 1-Methyl-3H-imidazole-2-thione 60-56-0Y 1349907 6649 DB00763Y 1131173Y 554Z48XN5E D00401Y CHEBI:50673Y ChEMBL1515Y DTXSID4020820 Interactive image Cn1cc[nH]c1=S InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)YKey:PMRYVIKBURPHAH-UHFFFAOYSA-NY Thiamazole, also known asmethimazole, is a medication used to treathyperthyroidism.This includesGraves' disease,toxic multinodular goiter, andthyrotoxic crisis.It is taken by mouth.Full effects may take a few weeks to occur. Common side effects include itchiness, hair loss, nausea, muscle pain, swelling, and abdominal pain.Severe side effects may includelow blood cell counts,liver failure, andvasculitis.Use is not recommended during thefirst trimesterofpregnancydue to the risk of congenital anomalies, but it may be used in thesecond trimesterorthird trimester.It may be used duringbreastfeeding.Those who developed significant side effects may also have problems withpropylthiouracil.Thiamazole is a cyclicthioureaderivative that works by decreasing the production ofthyroid hormones. Thiamazole was approved for medical use in the United States in 1950.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.It is also available in Europe and Asia.In 2023, it was the 255th most commonly prescribed medication in the United States, with more than 1million prescriptions.