What is Tiotropium used for?

Tiotropium is used as maintenance treatment ofchronic obstructive pulmonary disease(COPD).It may also be used as an add-on therapy in people with moderate-to-severe asthma on medium to high dose inhaled corticosteroids (ICS).It is not however approved foracute exacerbations of COPDor acute worsening of asthma. Tiotropium is also used in a combination inhaler witholodaterol, along-acting beta-agonist, for the treatment of COPD, under the brand namesStioltoandSpioltoamong others.

What pharmaceutical form is Tiotropium available in?

Tiotropium: Proszek do inhalacji w kapsułce twardej 10 mcg/dawkę dostarczoną (wziewna)

Is Tiotropium OTC or prescription only?

Tiotropium requires a doctor's prescription.

What are the side effects of Tiotropium?

Adverse effects are mainly related to itsantimuscariniceffects. Commonadverse drug reactions(≥1% of people) include: dry mouth and/or throat irritation. Rarely (<0.1% of patients) treatment is associated with:urinary retention, constipation, acuteangle closure glaucoma, palpitations (notablysupraventricular tachycardiaandatrial fibrillation) and allergy (rash,angioedema,anaphylaxis).A 2006 review found the increase in bronchospasm was small and did not reach statistical signifi

Can Tiotropium be used during pregnancy?

( AHT ) For the active ingredient tiotropium You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.

What precautions should be taken with Tiotropium?

• Caution should be exercised in patients with history of trouble urinating, enlarged prostate, bladder blockage, glaucoma, kidney problems, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding. • Do not swallow the capsule, it should be used with a special inhaler. • It may cause dizziness or blurred vision, do not drive a car or operate machinery while taking this medication. • Avoid contact with eyes.

What ATC class does Tiotropium belong to?

Tiotropium: ATC R03BB04. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

Tiotropium

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

USDailyMed:Tiotropium bromide AU:B1 R03BB04(WHO) AU:S4(Prescription only)UK:POM(Prescription only)US:℞-only (1α,2β,4β,7β)-7-[(hydroxidi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide 136310-93-5Y186691-13-4(cation) 54874265487427 367 DBSALT000348DB01409 10482095Y XX112XZP0J0EB439235FY D01929 CHEBI:90959CHEBI:90960 ChEMBL3545181ChEMBL1900528 0HK (PDBe,RCSB PDB) DTXSID5044281 Interactive imageInteractive image C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-]C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2‍‍‍‍‍‍‍,1-2H3;1H/q+1;/p-1/t11?,12-,13+,16-,17+;YKey:DQHNAVOVODVIMG-RGECMCKFSA-MYInChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16-,17-/m0/s1YKey:LERNTVKEWCAPOY-FPISHFTHSA-NY Tiotropium bromide, sold under the brand nameSpirivaamong others, is a long-actingbronchodilator(LAMA: long acting muscarinic antagonist) used in the management ofchronic obstructive pulmonary disease(COPD) andasthma.Specifically it is used during periods of breathing difficulty to prevent them from getting worse, rather than to prevent them from happening.It is used by inhalation through the mouth.Onset typically begins within half an hour and lasts for 24 hours. Common side effects include a dry mouth, runny nose, upper respiratory tract infection, shortness of breath and headache.Severe side effects may includeangioedema, worseningbronchospasm, andQT prolongation.Tentative evidence has not found harm duringpregnancy, however, such use has not been well studied.It is ananticholinergicmedication and works by blockingacetylcholineaction onsmooth muscle. Tiotropium was patented in 1989, and approved for medical use in 2002.It is on theWorld Health Organization's List of Essential Medicines.In 2023, it was the 163rd most commonly prescribed medication in the United States, with more than 3million prescriptions.

Tiotropium

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