RIMEVAX

J07BD01(WHO) UK:POM(Prescription only)US:℞-only 1704515-59-2Y none D04866 Measles vaccineprotects against becoming infected withmeasles.Nearly all of those who do not develop immunity after a single dose develop it after a second dose.When the rate ofvaccinationwithin apopulationis greater than 92%,outbreaksof measles typically no longer occur; however, they may occur again if the rate of vaccination decreases.Thevaccine's effectiveness lasts many years.It is unclear if it becomes less effective over time.The vaccine may also protect against measles if given within a couple of days after exposure to measles. Measles is a highly contagious viral illness that can lead to serious complications, including pneumonia, acute encephalitis, and, in rare cases, long‑term neurological disease. Pregnant women are at increased risk of severe respiratory complications and adverse pregnancy outcomes such as pregnancy loss and premature birth. The vaccine is generally safe, even for those infected byHIV.Most children do not experience any side effects;those that do occur are usually mild (such as fever, rash, pain at the site of injection, and joint stiffness) and short-lived.Anaphylaxishas been documented in about 3.5–10 cases per million doses.Rates ofGuillain–Barré syndrome,autismandinflammatory bowel diseasedo not appear to be increased by measles vaccination. The vaccine is available bothby itselfand in combinations such as theMMR vaccine(a combination with therubella vaccineandmumps vaccine)or theMMRV vaccine(a combination of MMR with thechickenpox vaccine).The measles vaccine is equally effective for preventing measles in all formulations, but side effects vary for different combinations.TheWorld Health Organization(WHO) recommends measles vaccine be given at nine months of age in areas of the world where the disease is common, or at twelve months where the disease is not common.Measles vaccine isbased on a live but weakened strainof measles.It comes as a dried powder that is mixed with aspecific liquidbefore being injected either just under the skin or into a muscle.Verification that the vaccine was effective can be determined by blood tests. The measles vaccine was first introduced in 1963.In that year, the Edmonston-B strain of measles virus was turned into a vaccine byJohn Endersand colleagues and licensed in the United States.In 1968, an improved and even weaker measles vaccine was developed byMaurice Hillemanand colleagues, and began to be distributed, becoming the only measles vaccine used in the United States since 1968.About 86% of children globally had received at least one dose of the vaccine as of 2018.In 2021, at least 183 countries provided two doses in their routine immunization schedule.It is on theWorld Health Organization's List of Essential Medicines.As outbreaks easily occur in under-vaccinated populations, non-prevalence of disease is seen as a test of sufficient vaccination within a population.