Bupropion

Bupropion is an active substance from the group of antidepressants, used for the treatment of depression and smoking cessation.‍‍‍‍‍‍​​​‍​​​​​​ Its effects are based on the inhibition of the reuptake of norepinephrine and dopamine in the central nervous system. Depending on the indication, the tablets are taken once or twice daily regardless of meals. The most common possible adverse effects include headache, dry mouth, gastrointestinal complaints such as nausea and vomiting, and insomnia. Seizures may occur rarely. Bupropion is a substrate and inhibitor of CYP2D6 and has a corresponding interaction potential. Bupropion (ATC N06AX12, ATC N07BA02) has antidepressant, noradrenergic, and dopaminergic properties. It inhibits the withdrawal symptoms triggered by smoking cessation. The effects are based on the inhibition of the reuptake of norepinephrine and dopamine. Bupropion and its metabolites have a long half-life of between 20 to 37 hours. Mechanism of action of reuptake inhibitors, click to enlarge. Illustration © PharmaWiki.